NEDD8



NEDD8 is a ubiquitin-like protein in human. It facilitates ubiquitin conjugation. It participates in the recruitment of E2 to the ubiquitin ligase complex. NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase. In yeast the protein is called Rub1. The images at the left and at the right correspond to one representative NEDD8, i.e. the crystal structure of NEDD8 (1ndd). Cl and SO4 are shown as space filling objects.

NEDD8
1ndd - hNEDD8 - human

2ko3 – hNEDD8 – NMR

NEDD8+ubiquitin-activating enzyme E1
3gzn – hNEDD8+hE1 regulatory and catalytic subunits

3dbh, 3dbl, 3dbr - hNEDD8+hE1 regulatory and catalytic subunits (mutant)

2nvu - hNEDD8+hE1 regulatory subunit+MBP/E1 catalytic subunit+UBC12

1r4m - hNEDD8+hE1C+amyloid beta precursor protein

1r4n - hNEDD8+hE1C+amyloid beta precursor protein+ATP

NEDD8+other proteins
3dqv – hNEDD8+CUL-5

2bkr – hNEDD8+NEDP1

1xt9 – hNEDD8+DEN1

Rub1
1bt0 – Rub1 – Arabidopsis thaliana